Healthcare

Cofactor Genomics

Website

Cofactor uses RNA and Predictive Immune Modeling to build better biomarkers and improve patient outcomes. Led by Jarret Glasscock and a group of expert human genome scientists,Cofactor has built a new category of diagnostic technology powered by unique and powerful RNA data models built on terabytes of data. The team recently had their techn

Founded 2015Origin source ↗Checked 2026-09-15

Overview

Cofactor uses RNA and Predictive Immune Modeling to build better biomarkers and improve patient outcomes.

Led by Jarret Glasscock and a group of expert human genome scientists,Cofactor has built a new category of diagnostic technology powered by unique and powerful RNA data models built on terabytes of data.

The team recently had their technology validation peer-reviewed by the organizations that set standards for diagnostic technology (CAP, AMP) and is publishing in the Journal of Molecular Diagnostics. In addition, the team made news when Cancer Physicians who sit on the committee for patient treatment guidelines (NCCN) presented a clinical study using Cofactor’s technology showing superiority in predicting the patients who will respond to immunotherapy. This initial application is an acute problem recognized widely in the rapidly developing immunotherapy industry and represents north of a billion dollar TAM.

After a number of recent key milestones, the team is taking the technology more broadly to 50% of cancers diagnosed in the US.

Current investors include Menlo Ventures, DCVC, and Ascension Ventures (this last investor representing the funding arm for 13 National U.S. Healthcare Systems).

Company description As recorded 2026-11-08
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Founders & team

Dave Messina

Founder/COO

Dr. Dave Messina has over 25 years of experience in healthcare and has been leading healthcare investments at Pioneer Fund since 2019. He has led 100+ deals including top portfolio companies like Gilgamesh ($1B exit to Abbvie) and Assort Health ($500M+ valuation). Previously he founded the RNA and machine learning company Cofactor Genomics (YC S15) and led it to national Medicare reimbursement. Dr. Messina also worked on the Human Genome Project.

X
Founder profile As recorded 2026-09-15
13team members reported
Source-reported As recorded 2026-09-15

Founded 2015 · Source

News & product activity

Sources & observations

Y Combinator

Profile depthverified profile
Website observationwebsite reachable
Last website check2026-11-11
Location · source statedSt. Louis, MO, USA
Pricing evidenceNo pricing page confirmed
Maturity: Not assessed · 3 of 6 areas documented

Source-based assessment · automated evidence rules

The retained text does not establish product availability or customer use.

Maturity is an evidence-based assessment, not a success rating. It may understate the current stage where evidence is limited. Coverage records documented areas, not a complete or independently audited company history.

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