Healthcare

Ophelia

Website

Ophelia helps people quit opioids without going to rehab. We offer online doctor’s visits, withdrawal medication prescriptions, and support for long-term recovery, using a protocol 6x more effective than most rehabs (2/3rds of which don't have doctors). More than 3 million Americans are addicted to opioids, but 80% are not getting help, due to j

Founded 2019Origin source ↗Checked 2026-09-15

Overview

Ophelia helps people quit opioids without going to rehab. We offer online doctor’s visits, withdrawal medication prescriptions, and support for long-term recovery, using a protocol 6x more effective than most rehabs (2/3rds of which don't have doctors).

More than 3 million Americans are addicted to opioids, but 80% are not getting help, due to jobs, families, and privacy concerns. Meanwhile, there's a proven treatment that increases survival rates by 600%, and it's low cost, discreet, and convenient. It's called MAT, and it looks like treatment for anxiety or depression: medication plus therapy. However, doctors need a special waiver to prescribe the medication, which fewer than 5% of them have, so it's difficult to get, and most people are buying it on the street. Sadly, drug dealers aren't doctors: every 11 minutes another American dies of an opioid overdose, now the #1 cause of death for Americans under 50.

Ophelia is replacing rehab with telemedicine, using proven science and a consumer-first approach. The opioid treatment market in the U.S. is $15B, and 85% of opioid addicts have insurance that pays for it. We're treating roughly 400 patients with thousands more waiting.

Zack started Ophelia after losing his girlfriend to an opioid overdose, who found it easier to get medication from a drug dealer than a doctor. We are raising money to help patients in waiting, grow our footprint, save lives, and earn venture-level returns for investors.

Company description As recorded 2026-11-08

Founders & team

Mattan Griffel

Founder

Mattan is an award-winning faculty member at Columbia Business School and a two-time Y Combinator-backed entrepreneur. He co-founded Ophelia, a company that helps people quit opioids without having to go to rehab. Mattan is also an Innovation Fellow at the Lang Center for Entrepreneurship at Columbia Business School and was selected as one of Forbes' 30 Under 30 in Education. I studied Philosophy and Finance at New York University and wrote my thesis on the metaphysics of consciousness.

Founder profile As recorded 2026-09-15
250team members reported
Source-reported As recorded 2026-09-15

Founded 2019 · Source

News & product activity

Sources & observations

Y Combinator

Profile depthenriched profile
Website observationwebsite reachable
Last website check2026-11-11
Location · source statedNew York City, NY, USA; New York, NY, USA
Pricing evidenceA pricing page was detected
Maturity: Launched · 4 of 6 areas documented

Source-based assessment · automated evidence rules

The company website offers product access through a trial, free start, app download, purchase, or onboarding with existing-account login. Customer adoption is not established by this evidence.

Company website: home Checked 2026-09-23 · Company website: home Checked 2026-09-23 · Company website: home Checked 2026-09-23

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Maturity is an evidence-based assessment, not a success rating. It may understate the current stage where evidence is limited. Coverage records documented areas, not a complete or independently audited company history.

Stage definitions
independent websitesource corroborationreachable websitedescriptive evidenceclassified market and modelsourced peoplesourced founding yearpricing page observed