Biotech pharma

Perlara

Website

Perlara 1.0 (Feb 2014 - Feb 2019) launched early R&D joint ventures called PerlQuests with highly motivated rare disease families, companies or impact investors. We screened gene-edited patient avatars for repurposable drugs in order to build a predictive R&D engine called ArkBase. We planned to monetize programs based on ArkBase predictions by sel

Founded 2014Origin source ↗Checked 2026-09-15

Overview

Perlara 1.0 (Feb 2014 - Feb 2019) launched early R&D joint ventures called PerlQuests with highly motivated rare disease families, companies or impact investors. We screened gene-edited patient avatars for repurposable drugs in order to build a predictive R&D engine called ArkBase. We planned to monetize programs based on ArkBase predictions by selectively spinning out asset-centric clinical development NewCos.

Perlara 1.5 (March 2019 - April 2020) was the transition to a one-person virtual clinical development company and when the epalrestat and aripiprazole repurposing trials were launched at Mayo Clinic for the treatment of PMM2-CDG and NGLY1-CDDG, respectively.

Perlara 2.0 (May 2020 --> The first decentralized and distributed biotech

Company description As recorded 2026-11-08
About
Biotech pharmaBusinessesServices

Founders & team

Previously Perlstein Lab PBC

Company history As recorded 2026-11-08

No directly sourced team information is available yet.

1team members reported
Source-reported As recorded 2026-09-15

Founded 2014 · Source

News & product activity

Sources & observations

Y Combinator

Profile depthverified profile
Website observationwebsite reachable
Last website check2026-11-11
Location · source statedSan Francisco, CA, USA; Oakland, CA, USA; Remote
Pricing evidenceNo pricing page confirmed
Maturity: Not assessed · 2 of 6 areas documented

Source-based assessment · automated evidence rules

The retained text does not establish product availability or customer use.

Maturity is an evidence-based assessment, not a success rating. It may understate the current stage where evidence is limited. Coverage records documented areas, not a complete or independently audited company history.

Stage definitions
independent websitesource corroborationreachable websitedescriptive evidenceclassified market and modelsourced founding year
startup.observe Directory coverage · Sources & method